Which of the following is a side effect of Premarin?

Premarin, which is a conjugated estrogen medication, can indeed cause headaches as a side effect. Estrogen can lead to changes in blood flow and hormonal balance, which may contribute to the development of headaches in some individuals. This side effect is relatively common among users of hormone replacement therapies like Premarin, as it can interact with neurotransmitter systems in the brain that are involved in pain regulation.

While fatigue, changes in urine color, and dizziness may also occur in some patients, headaches are a well-documented and frequently reported side effect specific to estrogen-based treatments, making headaches the most fitting choice in this context. By recognizing the common side effect profile of Premarin, individuals can better monitor their response to the medication and discuss any concerns with their healthcare provider.